Counterintuitive doses

published Jan 15, 2009, last modified Jun 26, 2013

Sometimes, half the medicine has double the effect. Now we know why.

The Last Psychiatrist has the scoop.  Finally, an explanation for why half a tab of Remeron can knock you out cold for 15 hours, but the full tab only for eight.  It's really all about thresholds: e.g. Remeron is marketed as an antidepressant and anti-insomniac, but the effects are totally different depending on the dose.

But don't let me keep you here, go and read the article I linked -- it has a better explanation.

Incidentally, if you ever want to spend a full night in deep, repairing sleep, there's nothing like Remeron.  Just don't have only half a tab -- unless you have sixteen hours to spare.