Counterintuitive doses

published Jan 15, 2009, last modified Jun 26, 2013

Sometimes, half the medicine has double the effect. Now we know why.

The Last Psychiatrist has the scoop .  Finally, an explanation for why half a tab of Remeron can knock you out cold for 15 hours, but the full tab only for eight.  It's really all about thresholds: e.g. Remeron is marketed as an antidepressant and anti-insomniac, but the effects are totally different depending on the dose.

But don't let me keep you here, go and read the article I linked -- it has a better explanation.

Incidentally, if you ever want to spend a full night in deep, repairing sleep, there's nothing like Remeron.  Just don't have only half a tab -- unless you have sixteen hours to spare.